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Distributed manufacturing (DM) is a production model that decentralizes manufacturing processes, enabling products to be designed, produced, and distributed closer to end-users. This shift from centralized production to localized networks offers advantages such as increased flexibility, cost efficiency, and local empowerment.
The openness of "open manufacturing" may relate to the nature of the product (open design), to the nature of the production machines and methods (e.g. open source 3D-printers, open source CNC), to the process of production and innovation (commons-based peer production / collaborative / distributed manufacturing), or to new forms of value creation (network-based bottom-up or hybrid versus ...
Overhauled diagram, properly labeled, larger default size: 22:14, 14 August 2020: 300 × 266 (44 KB) Cgardner65536: Made the diagram "even more decentralized" by re-arranging some of the connecting lines away from the center node. 01:19, 30 August 2014: 300 × 266 (43 KB) Kes47
Exagamglogene autotemcel is the first cell-based gene therapy treatment utilizing CRISPR/Cas9 gene editing technology to be approved by the US Food and Drug Administration (FDA). [13] The most common side effects include low levels of platelets and white blood cells, mouth sores, nausea, musculoskeletal pain, abdominal pain, vomiting, febrile ...
Axicabtagene ciloleucel (KTE-C19, ZUMA-3, YESCARTA) was an investigational therapy (for the treatment of adult patients with relapsed or refractory acute lymphoblastic leukemia (ALL)) in which a patient's T cells were genetically modified to express a chimeric antigen receptor designed to target the antigen CD19, a protein expressed on the cell surface of B-cell lymphomas and leukemias. [11]
Diagram from the National Cancer Institute (NCI) depicting the classical method of constructing a CAR-T cell for therapy. Production of CAR-T cells involve removal of T cells via an extraction process known as leukapheresis , followed by cell culture with viral vectors containing ingredients needed to construct the chimeric system.
Intraoperative blood salvage (IOS), also known as cell salvage, is a specific type of autologous blood transfusion. Specifically IOS is a medical procedure involving recovering blood lost during surgery and re-infusing it into the patient. It is a major form of autotransfusion.
Biomanufacturing products are recovered from natural sources, such as blood, or from cultures of microbes, animal cells, or plant cells grown in specialized equipment. The cells used during the production may have been naturally occurring or derived using genetic engineering techniques. [citation needed]