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Serum or plasma quetiapine concentrations are usually in the 1–10 mg/L range in overdose survivors, while postmortem blood levels of 10–25 mg/L are generally observed in fatal cases. [63] Non-toxic levels in postmortem blood extend to around 0.8 mg/kg, but toxic levels in postmortem blood can begin at 0.35 mg/kg.
Alcohol can exacerbate the symptoms and may directly contribute to increased severity of symptoms. The reasons for toxicity vary depending on the mixture of drugs. Usually, most victims die after using two or more drugs in combination that suppress breathing, and the low blood oxygen level causes brain death.
Much of the evidence for the off-label use of antipsychotics ... (Seroquel) – Of the ... Very toxic in overdose due to the potential for renal failure and seizures.
Antipsychotics by class Generic name Brand names Chemical class ATC code Typical antipsychotics; Acepromazine: Atravet, Acezine: phenothiazine: N05AA04
[38] [2] She was also prescribed 750 milligrams of Depakote and 200 milligrams of Seroquel, but the latter was not present in her body at the time of the autopsy. [5] [d] The girl's heart and lungs showed signs of damage due to ongoing prescription drug overuse, [31] and her lungs contained bloody fluid indicating a pulmonary edema. [39] [18]
As of 2016, benzodiazepines were most likely to cause fatal overdose in Australia, [20] with diazepam (Valium) being the drug most responsible. [12] While fatal overdoses are highly associated with drugs such as opiates, cocaine and alcohol, [ 2 ] deaths from other drugs such as caffeine are extremely rare.
The CDC reported recently that heroin-related overdose deaths jumped 39 percent nationwide between 2012 and 2013, surging to 8,257. In the past decade, Arizona’s heroin deaths rose by more than 90 percent. New York City had 420 heroin overdose deaths in 2013 — the most in a decade.
Seroquel and Seroquel XR – atypical antipsychotic used to treat schizophrenia and bipolar disorder. Used off-label to treat insomnia; Sonata – a non-benzodiazepine hypnotic; Spravato – a rapid-acting antidepressant of the NMDA receptor antagonist class; enantiomer of ketamine