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  2. Management of acute coronary syndrome - Wikipedia

    en.wikipedia.org/wiki/Management_of_acute...

    Chewing non−enteric-coated aspirin is encouraged (unless there are contraindications). Patients should stay calmed in a comfortable position. In case of heart attack, [14] it would not usually be lying down, but sitting down or sitting down with folded knees (but patients would notice the position that fits for them).

  3. Mechanism of action of aspirin - Wikipedia

    en.wikipedia.org/wiki/Mechanism_of_action_of_aspirin

    Additionally, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduces leukocyte adhesion, which is an important step in immune response to infection. There is currently insufficient evidence to show that aspirin helps to fight infection. [18]

  4. Enteric coating - Wikipedia

    en.wikipedia.org/wiki/Enteric_coating

    An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]

  5. Aspirin - Wikipedia

    en.wikipedia.org/wiki/Aspirin

    Enteric coating on aspirin may be used in manufacturing to prevent release of aspirin into the stomach to reduce gastric harm, but enteric coating does not reduce gastrointestinal bleeding risk. [188] [189] Enteric-coated aspirin may not be as effective at reducing blood clot risk.

  6. Osmotic-controlled release oral delivery system - Wikipedia

    en.wikipedia.org/wiki/Osmotic-controlled_Release...

    [1] [4] Osmotic agents such as sodium chloride, potassium chloride, or xylitol are added to both the drug and push layers to increase the osmotic pressure. [ 1 ] [ 4 ] [ 5 ] The initial design developed in 1982 by ALZA researchers was designated the Push-Pull Osmotic Pump (PPOP), and Procardia XL ( nifedipine ) was one of the first drugs to ...

  7. Nonsteroidal anti-inflammatory drug - Wikipedia

    en.wikipedia.org/wiki/Nonsteroidal_anti...

    Aspirin, the only NSAID able to irreversibly inhibit COX-1, is also indicated for antithrombosis through inhibition of platelet aggregation. This is useful for the management of arterial thrombosis, and prevention of adverse cardiovascular events like heart attacks. Aspirin inhibits platelet aggregation by inhibiting the action of thromboxane A ...

  8. Discovery and development of proton pump inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    It is available as delayed-release capsules or tablets and as esomeprazole sodium for intravenous injection/infusion. Oral esomeprazole preparations are enteric-coated, due to the rapid degradation of the drug in the acidic condition of the stomach. This is achieved by formulating capsules using the multiple-unit pellet system.

  9. Route of administration - Wikipedia

    en.wikipedia.org/wiki/Route_of_administration

    Enteric coated tablets are designed to dissolve in the intestine, not the stomach, because the drug present in the tablet causes irritation in the stomach. Administering medication rectally. The rectal route is an effective route of administration for many medications, especially those used at the end of life.

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