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Phenylglycine is the organic compound with the formula C 6 H 5 CH(NH 2)CO 2 H. It is a non-proteinogenic alpha amino acid related to alanine, but with a phenyl group in place of the methyl group. It is a white solid. The compound exhibits some biological activity. [1]
[1] (S)-DHPG has been investigated for therapeutic effects in the treatment of neuronal injury (such as those associated with ischemia or hypoxia), cognitive enhancement, and Alzheimer's disease. [1] 3,5-Dihydroxyphenylglycine can be isolated from the latex of Euphorbia helioscopia. [2] DHGP is also found in vancomycin and related glycopeptides.
4-Hydroxyphenylglycine (HPG) is a non-proteogenic amino acid found in vancomycin and related glycopeptides. HPG is synthesized from the shikimic acid pathway and requires four enzymes to synthesize: [1] Both L- and D-HPG are used in the vancomycin class of antibiotics.
This page was last edited on 17 September 2023, at 15:28 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
DAPT is a chemical compound used in the study of the Notch signaling pathway. [1] DAPT is a γ-secretase inhibitor. It indirectly inhibits Notch, which is a substrate for γ-secretase. [2] In a mouse model of Alzheimer's disease, DAPT reduces the levels of beta-amyloid. [3]
D 1 and D 2 receptors interact primarily through discrete amino acids in the cytoplasmic regions of each receptor, with no involvement of transmembrane parts. The intracellular loop 3 of the D 2 receptor contains two adjacent arginine residues, while the carboxyl tail of the D 1 receptor possesses two adjacent glutamic acid residues.
Azlocillin synthesis: FR 2100682 eidem U.S. patent 3,933,795 [2] Azlocillin synthesis 2: [2] [3] An interesting alternative synthesis of azlocillin involves activation of the substituted phenylglycine analogue 1 with 1,3-dimethyl-2-chloro-1-imidazolinium chloride ( 2 ) and then condensation with 6-APA .
Prostaglandin D 2 (or PGD 2) is a prostaglandin that binds to the receptor PTGDR (DP 1), as well as CRTH2 (DP 2). [1] [2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD 2 are found only in the brain and in mast cells.