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In March 2017, ocrelizumab was approved in the United States for the treatment of primary progressive multiple sclerosis in adults. [22] [42] It is also used for the treatment of relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults. [42]
The trial will lead to the creation of 19 sites around the country where this treatment can be delivered, which will increase the UK capacity to offer the treatment for MS patients.
There is a huge need for effective treatments for people with MS, as Astbury concluded: “More than 150,000 people live with MS in the U.K., and many don’t have access to any treatments.
Unusual types of MS have been described; these include Devic's disease, Balo concentric sclerosis, Schilder's diffuse sclerosis, and Marburg multiple sclerosis. There is debate on whether they are MS variants or different diseases. [31] Multiple sclerosis behaves differently in children, taking more time to reach the progressive stage. [5]
Fatigue is one of the most common symptoms of MS. [26] [27] Roughly 65% of people with MS experience fatigue symptomatology, and of these, some 15–40% report fatigue as their most disabling MS symptom.
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