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The colorectal adenoma is a benign glandular tumor of the colon and the rectum. It is a precursor lesion of the colorectal adenocarcinoma ( colon cancer ). [ 1 ] [ 2 ] [ 3 ] They often manifest as colorectal polyps .
Adenomatous polyp colon with malignant focus at apex. A colorectal polyp is a polyp (fleshy growth) occurring on the lining of the colon or rectum . [ 1 ] Untreated colorectal polyps can develop into colorectal cancer .
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited condition in which numerous adenomatous polyps form mainly in the epithelium of the large intestine. While these polyps start out benign , malignant transformation into colon cancer occurs when they are left untreated.
Gardner's syndrome (also known as Gardner syndrome, familial polyposis of the colon, [1] or familial colorectal polyposis [2]) is a subtype of familial adenomatous polyposis (FAP). Gardner syndrome is an autosomal dominant form of polyposis characterized by the presence of multiple polyps in the colon together with tumors outside the colon. [3]
The adenomatous polyp is considered pre-malignant, i.e., likely to develop into colon cancer. [14] The other types of polyps that can occur in the colon are hyperplastic and inflammatory polyps, which are unlikely to develop into colorectal cancer. [15] About 5% of people aged 60 will have at least one adenomatous polyp of 1 cm diameter or ...
It was recommended starting at age 50 but it was changed to 45 due to increasing numbers of colon cancers. [10] [11] During colonoscopy, small polyps may be removed if found. [2] If a large polyp or tumor is found, a biopsy may be performed to check if it is cancerous.
The polyp removed from the president's colon last week was a benign, slow-growing but potentially pre-cancerous lesion that required no further action, his doctor said in a follow-up memo.
Traditional serrated adenoma seen under microscopy with H&E stain, showing serrated crypts. SPS may occur with one of two phenotypes: distal or proximal. [6] The distal phenotype may demonstrate numerous small polyps in the distal colon and rectum, whereas the proximal phenotype may be characterized by relatively fewer, but larger polyps in the proximal colon (cecum, ascending colon, etc.). [6]
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