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There are also a number of other conditions that affect hands, feet, and parts of the face with associated skin color changes that need to be differentiated from acrocyanosis: Raynaud phenomenon, pernio, acrorygosis, erythromelalgia, and blue finger syndrome. The diagnosis may be challenging in some cases, especially when these syndromes co-exist.
Cyanosis is the change of body tissue color to a bluish-purple hue, as a result of decrease in the amount of oxygen bound to the hemoglobin in the red blood cells of the capillary bed. [1] Cyanosis is apparent usually in the body tissues covered with thin skin , including the mucous membranes , lips, nail beds , and ear lobes. [ 1 ]
Argyria or argyrosis is a condition caused by excessive exposure to chemical compounds of the element silver, or silver dust. [1] The most dramatic symptom of argyria is that the skin turns blue or blue-gray, and is usually most prominent in sun-exposed areas of the skin.
Livedo reticularis is a common skin finding consisting of a mottled reticulated vascular pattern that appears as a lace-like purplish discoloration of the skin. [1] The discoloration is caused by reduction in blood flow through the arterioles that supply the cutaneous capillaries, resulting in deoxygenated blood showing as blue discoloration ().
Paul Karason (November 14, 1950 – September 23, 2013) was an American from Bellingham, Washington, whose skin was a purple-blue color. [1]Karason was fair skinned and freckled until the early 1990s.
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Methemoglobinemia, or methaemoglobinaemia, is a condition of elevated methemoglobin in the blood. [2] Symptoms may include headache, dizziness, shortness of breath, nausea, poor muscle coordination, and blue-colored skin (cyanosis). [2]
Porphyria / p ɔːr ˈ f ɪr i ə / is a group of disorders in which substances called porphyrins build up in the body, adversely affecting the skin or nervous system. [1] The types that affect the nervous system are also known as acute porphyria, as symptoms are rapid in onset and short in duration. [1]