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Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]
In 2006, the National Institute for Health and Care Excellence (NICE) guidelines recommended augmentative second-generation (atypical) antipsychotics for treatment-resistant OCD. [5] Atypical antipsychotics are not useful when used alone and no evidence supports the use of first-generation antipsychotics.
Treatment-resistant OCD is categorized as patients with a less than 25% reduction in their symptoms after 12 weeks of SSRI treatment. Deep brain stimulation (DBS) is a last-line option for treatment resistant OCD. [26] DBS is also a treatment for Parkinson's disease and involves using electrical signals to stimulate target brain areas. [31]
Evidence-based, trauma-focused psychotherapy is the first-line treatment for PTSD. [8] [9] [6] Psychotherapy is defined as a treatment where a therapist and patient build a therapeutic relationship and focus on the patient's thoughts, attitudes, affect, behavior, and social development to lessen the patient's psychopathologies and functional impairment.
Treatment for intrusive thoughts is similar to treatment for OCD. Exposure and response prevention therapy—also referred to as habituation or desensitization—is useful in treating intrusive thoughts. [21] Mild cases can also be treated with cognitive behavioral therapy, which helps patients identify and manage the unwanted thoughts. [12]
Vagus nerve stimulation therapy improved the symptoms of treatment-resistant depression for nearly 500 participants in a major clinical trial. ... “And the nice thing about vagus nerve ...
It may cause depressed patients to be noncompliant in their treatment, and the effects of certain substances can worsen the effects of depression. Other psychiatric disorders that may predict treatment-resistant depression include attention deficit hyperactivity disorder, [7] personality disorders, obsessive compulsive disorder, and eating ...
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