Search results
Results from the WOW.Com Content Network
An autophagosome is a spherical structure with double layer membranes. [2] It is the key structure in macroautophagy , the intracellular degradation system for cytoplasmic contents (e.g., abnormal intracellular proteins , excess or damaged organelles , invading microorganisms).
ATG may be part of the protein name (such as ATG7) or part of the gene name (such as ATG7), [53] although all ATG proteins and genes do not follow this pattern (such as ULK1). [ 52 ] To give specific examples, the UKL1 enzyme (kinase complex) induces autophagosome biogenesis, and ATG13 ( Autophagy-related protein 13 ) is required for phagosome ...
Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene. [5] LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes. [6]
Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. [5] This protein is characterized as a subunit of the autophagy-related ATG12-ATG5/ATG16 complex and is essentially important for the LC3 lipidation and autophagosome formation. This complex localizes to the membrane and is released just before or after ...
Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1.
9140 67526 Ensembl ENSG00000145782 ENSMUSG00000032905 UniProt O94817 Q9CQY1 RefSeq (mRNA) NM_001277783 NM_004707 NM_026217 RefSeq (protein) NP_001264712 NP_004698 NP_080493 Location (UCSC) Chr 5: 115.83 – 115.84 Mb Chr 18: 46.86 – 46.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Autophagy related 12 is a protein that in humans is encoded by the ATG12 gene. Autophagy is a ...
Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene. [5]ATG13 is an autophagy factor required for phagosome formation. . ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 comp
This substrate protein-chaperone complex binds to lysosome-associated membrane protein type 2A (LAMP-2A), which acts as the receptor for this pathway. [6] LAMP-2A a single span membrane protein, is one of the three spliced variants of a single gene lamp2 . [ 7 ]