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Oxymetazoline, sold under the brand name Afrin among others, is a topical decongestant and vasoconstrictor medication. It is available over-the-counter as a nasal spray to treat nasal congestion and nosebleeds, as eye drops to treat eye redness due to minor irritation, and (in the United States) as a prescription topical cream to treat persistent facial redness due to rosacea in adults.
Decongestant nasal sprays are advised for short-term use only, preferably 5 to 7 days at maximum. Some doctors advise to use them 3 days at maximum. A recent clinical trial has shown that a corticosteroid nasal spray may be useful in reversing this condition. [3] Topical nasal decongestants include: Oxymetazoline; Phenylephrine; Xylometazoline
The nasal spray prevents the glands in the nose from producing large amounts of fluid. [5] [6] It is used to treat rhinorrhea (runny nose) caused by allergic rhinitis, nonallergic rhinitis, [5] and the common cold. [7] [2] It is used by metered-dose manual pump spray. Onset of action is within an hour. [7]
The smaller arteries are also constricted and this causes the colour of the nasal epithelium to be visibly paler after dosage. Xylometazoline is an imidazole derivative which is designed to mimic the molecular shape of adrenaline. It binds to α 1 and α 2 adrenergic receptors [11] in the nasal mucosa.
Neffy, a single-dose nasal spray administered into one nostril, is approved for use in adult and pediatric patients who weigh at least 30 kilograms. "Some people, particularly children, may delay ...
U.S. health officials on Friday approved a nasal spray to treat severe allergic reactions, the first needle-free alternative to shots like EpiPen. The Food and Drug Administration said it approved ...
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