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  2. NFATC3 - Wikipedia

    en.wikipedia.org/wiki/NFATC3

    The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component.

  3. Behavioral epigenetics - Wikipedia

    en.wikipedia.org/wiki/Behavioral_epigenetics

    Behavioral epigenetics is the field of study examining the role of epigenetics in shaping animal and human behavior. [1] It seeks to explain how nurture shapes nature, [2] where nature refers to biological heredity [3] and nurture refers to virtually everything that occurs during the life-span (e.g., social-experience, diet and nutrition, and exposure to toxins). [4]

  4. NFATC1 - Wikipedia

    en.wikipedia.org/wiki/NFATC1

    The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family ...

  5. Linker for activation of T cells - Wikipedia

    en.wikipedia.org/wiki/Linker_for_activation_of_T...

    The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the LAT gene. [5] Alternative splicing results in multiple transcript variants encoding different isoforms. [6]

  6. Epigenetics of anxiety and stress–related disorders - Wikipedia

    en.wikipedia.org/wiki/Epigenetics_of_anxiety_and...

    Early life experiences, even when generations removed, can cause permanent epigenetic modifications of DNA resulting in changes in gene expression, endocrine function and metabolism. [1] These heritable epigenetic modifications include DNA methylation of the promoter regions of genes that affect sensitivity to stress.

  7. NFAT - Wikipedia

    en.wikipedia.org/wiki/NFAT

    T-cell receptor (TCR) stimulation causes the dephosphorylation of NFAT which in almost every kind of T cell then forms a complex with AP-1 (except in Tregs). This complex depending on the cytokine context then activates the key transcription factors of the distinct T cell subpopulations: T-bet for Th1, GATA3 for Th2, RORγ for Th17 and BATF for ...

  8. Immunoreceptor tyrosine-based activation motif - Wikipedia

    en.wikipedia.org/wiki/Immunoreceptor_tyrosine...

    ITAMs are important for signal transduction, mainly in immune cells. They are found in the cytoplasmic tails of non-catalytic tyrosine-phosphorylated receptors [7] such as the CD3 and ζ-chains of the T cell receptor complex, the CD79-alpha and -beta chains of the B cell receptor complex, and certain Fc receptors.

  9. XCL2 - Wikipedia

    en.wikipedia.org/wiki/XCL2

    It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1 . [ 6 ] Its gene is located on chromosome 1 in humans.