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  2. Autocrine signaling - Wikipedia

    en.wikipedia.org/wiki/Autocrine_signaling

    Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell. [1] This can be contrasted with paracrine signaling, intracrine signaling, or classical endocrine signaling.

  3. Linker for activation of T cells - Wikipedia

    en.wikipedia.org/wiki/Linker_for_activation_of_T...

    The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the LAT gene. [5] Alternative splicing results in multiple transcript variants encoding different isoforms. [6]

  4. Behavioral epigenetics - Wikipedia

    en.wikipedia.org/wiki/Behavioral_epigenetics

    Behavioral epigenetics is the field of study examining the role of epigenetics in shaping animal and human behavior. [1] It seeks to explain how nurture shapes nature, [2] where nature refers to biological heredity [3] and nurture refers to virtually everything that occurs during the life-span (e.g., social-experience, diet and nutrition, and exposure to toxins). [4]

  5. Epigenetics of anxiety and stress–related disorders - Wikipedia

    en.wikipedia.org/wiki/Epigenetics_of_anxiety_and...

    Early life experiences, even when generations removed, can cause permanent epigenetic modifications of DNA resulting in changes in gene expression, endocrine function and metabolism. [1] These heritable epigenetic modifications include DNA methylation of the promoter regions of genes that affect sensitivity to stress.

  6. NFATC1 - Wikipedia

    en.wikipedia.org/wiki/NFATC1

    The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family ...

  7. CD70 - Wikipedia

    en.wikipedia.org/wiki/CD70

    It is primarily expressed on highly activated T cells and B cells, as well as on NK cells and mature dendritic cells. CD70 expression on T and B cells is stimulated through triggering of T and B cell receptors and can be upregulated by cytokines such as IL-1α , IL-2 , IL-12 , GM-CSF and TNF-α , while IL-4 and IL-10 can decrease CD70 ...

  8. T-cell receptor - Wikipedia

    en.wikipedia.org/wiki/T-cell_receptor

    T cells need three signals to become fully activated. Signal 1 is provided by the T-cell receptor when recognising a specific antigen on a MHC molecule. Signal 2 comes from co-stimulatory receptors on T cell such as CD28, triggered via ligands presented on the surface of other immune cells such as CD80 and CD86. These co-stimulatory receptors ...

  9. XCL2 - Wikipedia

    en.wikipedia.org/wiki/XCL2

    It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1 . [ 6 ] Its gene is located on chromosome 1 in humans.