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Stereocilia (or stereovilli or villi) are non-motile apical cell modifications. They are distinct from cilia and microvilli , but are closely related to microvilli. They form single "finger-like" projections that may be branched, with normal cell membrane characteristics.
Resembling hair-like projections, the stereocilia are arranged in bundles of 30–300. [3] Within the bundles the stereocilia are often lined up in several rows of increasing height, similar to a staircase. At the core of these hair-like stereocilia are rigid cross-linked actin filaments, which can renew every
161497 140476 Ensembl ENSG00000242866 ENSMUSG00000033498 UniProt Q7RTU9 Q8VIM6 RefSeq (mRNA) NM_153700 NM_080459 RefSeq (protein) NP_714544 NP_536707 Location (UCSC) Chr 15: 43.6 – 43.62 Mb Chr 2: 121.19 – 121.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Stereocilin is a protein that in humans is encoded by the STRC gene. The STRC gene provides instructions for creating a ...
Each hair cell of a macula has 40 to 70 stereocilia and one true cilium called a kinocilium. The stereocilia are oriented by the striola, a curved ridge that runs through the middle of the macula; in the saccule they are oriented away from the striola [2] The tips of the stereocilia and kinocilium are embedded in a gelatinous otolithic membrane ...
The stereocilia atop the IHCs move with this fluid displacement and in response their cation, or positive ion selective, channels are pulled open by cadherin structures called tip links that connect adjacent stereocilia. [9] The organ of Corti, surrounded in potassium-rich fluid endolymph, lies on the basilar membrane at the base of the scala ...
the cochlear duct or scala media (containing endolymph) a region of high potassium ion concentration that the stereocilia of the hair cells project into; The helicotrema, the location where the tympanic duct and the vestibular duct merge, at the apex of the cochlea; Reissner's membrane, which separates the vestibular duct from the cochlear duct
Pseudostratified columnar epithelia with stereocilia are located in the epididymis. Stereocilia of the epididymis are not cilia because their cytoskeleton is composed of actin filaments, not microtubules. [3] They are structurally and molecularly more similar to microvilli than to true cilia. [dubious – discuss]
The fluid moves hair cells (stereocilia), and their movement generates nerve impulses which are then taken to the brain by the cochlear nerve. [81] [82] The auditory nerve takes the impulses to the brainstem, which sends the impulses to the midbrain. Finally, the signal goes to the auditory cortex of the temporal lobe to be interpreted as sound ...