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Arsenic trioxide is indicated in combination with tretinoin for treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia whose acute promyelocytic leukemia is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression; and for induction of remission and consolidation in patients with acute promyelocytic leukemia who are refractory to, or ...
The efficacy of arsenic trioxide has also been demonstrated in the treatment of multiple myeloma, in combination with ascorbic acid [56] and bortezomib. [ 57 ] Animal studies have shown that the drug also affects ovarian, [ 58 ] liver, stomach, [ 59 ] prostate, and breast cancers, [ 60 ] as well as gliomas [ 61 ] and pancreatic cancer (in ...
Arsenic trioxide (As 2 O 3) is currently being evaluated for treatment of relapsed/refractory disease. Remission with arsenic trioxide has been reported. [23] Studies have shown arsenic reorganizes nuclear bodies and degrades the mutant PML-RAR fusion protein. [23] Arsenic also increases caspase activity which then induces apoptosis. [23]
From 1865, Fowler's solution was a leukemia treatment. [2] [3] ... (FDA) approved a drug of arsenic trioxide to treat acute promyelocytic leukaemia, [5] ...
In homeopathy, arsenicum album (Arsenic. alb. ) is a solution prepared by diluting aqueous arsenic trioxide generally until there is little amounts of Arsenic remaining in individual doses. It is used by homeopaths to treat a range of symptoms that include digestive disorders and, as an application of the Law of Similars , has been suggested by ...
The syndrome is characterized by dyspnea, fever, weight gain, hypotension, and pulmonary infiltrates. This is effectively treated by giving dexamethasone and withholding ATRA (or arsenic trioxide) in severe cases. An elevated white count is sometimes associated with this syndrome, but is not always pathognomonic.
Dr. A. Thomas McLellan, the co-founder of the Treatment Research Institute, echoed that point. “Here’s the problem,” he said. Treatment methods were determined “before anybody really understood the science of addiction. We started off with the wrong model.” For families, the result can be frustrating and an expensive failure.
Arsenic poisoning (or arsenicosis) is a medical condition that occurs due to elevated levels of arsenic in the body. [4] If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. [1]