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Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists led by Simon Campbell [55] working at Pfizer's Sandwich, Kent, research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ). [ 56 ]
Sildenafil is the active ingredient in the medication and the name for generic Viagra. Viagra and Revatio are the drug’s brand names. Viagra doses range from 25 to 100 milligrams (mg). A typical ...
Sildenafil can still be used to treat hypertension, but today, the primary use of this PDE5 inhibitor is to remedy ED. Other first-line treatment options for blood pressure and heart disease are ...
Sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) typically start working within 30 to 60 minutes, while avanafil (Stendra) works within 15 to 30 minutes. As with most prescription ...
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
The PDE5 inhibitors sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis) are prescription drugs which are taken by mouth. [10]: 20–21 As of 2018, sildenafil is available in the UK without a prescription. [54]
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rexmd.com has been visited by 10K+ users in the past month