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Sylvain E. Lesné (born 1974) is a French neuroscientist and associate professor at the Department of Neuroscience at the University of Minnesota (UMN) Medical School, known for his research into Alzheimer's disease. He is the primary author of a controversial 2006 Nature paper, "A specific amyloid-β protein assembly in the brain impairs ...
In 2006, three of her research papers made a list of the eighteen papers that had contributed the most to Alzheimer's research. [20] Ashe is a co-author on a 2006 paper published in Nature (retracted in 2024 [10]), entitled "A specific amyloid-β protein assembly in the brain impairs memory".
Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...
A main theory behind the cause of Alzheimer’s disease is the build-up of the protein amyloid-beta in the brain. Researchers from the University of Cincinnati provide evidence suggesting it’s ...
There are 124 potential Alzheimer’s treatments now being tested in clinical trials to target beta-amyloid and tau, reduce inflammation, protect neurons, act on genes that increase Alzheimer’s ...
Crenezumab is a fully humanized monoclonal antibody against human 1-40 and 1-42 beta amyloid, which is being investigated as a treatment of Alzheimer's disease. [1] Crenezumab is highly homologous to solanezumab, another monoclonal antibody targeting amyloid-β peptides. [2]
Brandon Granger, the congresswoman's son, told The Post that his mother has exhibited signs of dementia. Inside the scandal over Texas Rep. Kay Granger’s mysterious disappearance from DC — and ...
Two amyloid plaques from the brain of a patient with Alzheimer's disease. In this photomicrograph, neurites are darkly stained with the Naoumenko-Feigin silver method, and the pink elements (including the plaque cores) are stained with the periodic acid-Schiff (PAS) counterstain. The bar is 20 microns (0.02 mm) in length.