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A meta-analysis for associations between PFASs and human clinical biomarkers for liver injury, analyzing PFAS effects on liver biomarkers and histological data from rodent experimental studies, concluded that evidence exists that PFOA, perfluorohexanesulfonic acid (PFHxS), and perfluorononanoic acid (PFNA) caused hepatotoxicity in humans. [80]
Dr. Carmen Marsit: PFAS are a class of about 15,000 human-made chemicals that contain fluorine groups, which give them special properties. They are in nonstick surfaces; they’re used in ...
Industrial usage of PFAS began in the 1940s, and their effects on human health were not identified for another 20 years. But even then, the chemicals continued to be used in manufacturing plants ...
“The existing evidence suggests that this compound can cause liver, developmental, blood and endocrine effects in the human body,” Jamie Alan, an associate professor of pharmacology and ...
10 January 2018 According to the U.S. Department of Health & Human Services's Agency for Toxic Substances and Disease Registry (ATSDR) website, which was last reviewed on10 January 2018, the "health effects of PFOS, PFOA, PFHxS, and PFNA have been more widely studied than other per- and polyfluoroalkyl substances (PFAS). Some, but not all ...
In humans, PFHxS binds to blood albumin, [8] and relatively little PFHxS is found in the liver compared to longer chain PFASs such as PFOS. [9] The half-life of PFHxS in adult blood serum is 5.3 years (4.7 years for women and 7.4 years for men). [10] The half-life of PFASs in human blood generally decreases with decreasing backbone (CF 2) length.
Most measurements of PFAS in humans are made with serum, a fluid derived from blood but without coagulants or red blood cells, which requires the presence of a medical professional, said Stapleton.
Aug. 3—Most likely, you're aware of PFAS. Or at least your bloodstream is, considering that the chemicals have been detected in 98% of Americans, according to the National Health and Nutrition ...