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Naproxen, sold under the brand name Aleve among others, is a nonsteroidal anti-inflammatory drug ... It is metabolized by the liver to inactive metabolites. [8]
Metabolism may be abnormal in certain disease states, and accumulation may occur even with normal dosage. [medical citation needed] NSAIDs can also be divided into short-acting (plasma half-life less than 6 h) such as aspirin, diclofenac and ibuprofen and long-acting (half-life approximately greater than 10 h) such as naproxen, celecoxib. [156]
Ibuprofen, like other 2-arylpropionate derivatives such as ketoprofen, flurbiprofen and naproxen, contains a stereocenter in the α-position of the propionate moiety. The product sold in pharmacies is a racemic mixture of the S and R -isomers.
See the list of steroid metabolism modulators instead for steroid/sterol-specific CYP450s, including: CYP7A1 (cholesterol 7α-hydroxylase) CYP7B1 (25-hydroxycholesterol 7α-hydroxylase) CYP8B1 (sterol 12α-hydroxylase) CYP11A1 (cholesterol side-chain cleavage enzyme; P450scc) CYP11B1 (steroid 11β-hydroxylase) CYP11B2 (aldosterone synthase)
Naproxcinoid is metabolized to naproxen and a nitric oxide donating moiety. NO has various cardiovascular effects, including vasodilatory and platelet-inhibitory actions as well as the inhibition of vascular smooth muscle proliferation that serves to maintain normal vascular tone. [11]
IL-6 and irisin are mainly released from skeletal muscle and play a role in metabolism as well, with studies showing increased levels of IL-6 are associated with appetite suppression (decreased ...
[153] [154] Naproxen has been shown to be as effective as aspirin and less toxic, but due to the limited clinical experience, naproxen is recommended only as a second-line treatment. [ 153 ] [ 155 ] Along with rheumatic fever, Kawasaki disease remains one of the few indications for aspirin use in children [ 156 ] in spite of a lack of high ...
This article was reviewed by Daniel Z. Lieberman, MD. If you’ve been diagnosed with major depressive disorder or a form of anxiety, your mental health provider may prescribe the medication Lexapro.