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Lewy neurites are abnormal neurites in diseased neurons, containing granular material and abnormal α-synuclein filaments similar to those found in Lewy bodies. [20] Like Lewy bodies, Lewy neurites are a feature of α-synucleinopathies such as dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. [21]
Lewy body dementia (LBD) is an umbrella term for two similar and common subtypes of dementia: [1] dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD).
Dementia with Lewy bodies (DLB) is a type of dementia, a group of diseases involving progressive neurodegeneration of the central nervous system. [11] It is one of the two Lewy body dementias, along with Parkinson's disease dementia.
Lewy body dementia, which is the condition actor Robin Williams was diagnosed with before his death, is linked with abnormal deposits of protein in the brain known as Lewy bodies, the NIA explains.
Lewy Body Dementia (LBD) is the second-most common form of dementia after Alzheimer’s disease; However, unlike most well-known forms of dementia, LBD isn’t characterized by memory loss.
Alpha-synuclein is the primary structural component of Lewy body fibrils. Occasionally, Lewy bodies contain tau protein; [100] however, alpha-synuclein and tau constitute two distinctive subsets of filaments in the same inclusion bodies. [101] Alpha-synuclein pathology is also found in both sporadic and familial cases with Alzheimer's disease ...
The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response.
David Gergen, a political commentator who’s served in the White House under four presidents, has been diagnosed with dementia, his daughter revealed in The Boston Globe. Gergen, 82, has Lewy ...