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The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. [1]
[citation needed] It is a major site for blood filtration (including glomerulus) Any proteins under roughly 30 kilodaltons can pass freely through the membrane, although there is some extra hindrance for negatively charged molecules due to the negative charge of the basement membrane and the podocytes. [citation needed]
The glomerulus receives its blood supply from an afferent arteriole of the renal arterial circulation. Unlike most capillary beds, the glomerular capillaries exit into efferent arterioles rather than venules. The resistance of the efferent arterioles causes sufficient hydrostatic pressure within the glomerulus to provide the force for ...
A heart attack occurs when the blood flow to your heart is blocked. The most common cause is coronary artery disease. Heart attacks are medical emergencies that require immediate medical attention ...
The renal corpuscle is composed of two structures, the glomerulus and the Bowman's capsule. [3] The glomerulus is a small tuft of capillaries containing two cell types. Endothelial cells, which have large fenestrae, are not covered by diaphragms. Mesangial cells are modified smooth muscle cells that lie between the capillaries.
This can cause an increase of fluid pressure within the glomeruli, thus causing their hypertrophy, or breakdown. [10] Amyloidosis: This disease causes the buildup abnormal proteins called amyloid fibrils. Depositions of amyloid fibrils in the kidneys will eventually lead it to the primary filtration unit, the glomerulus, and cause blockages.
Most heart attacks are caused by atherosclerosis. Other causes include a blood clot that travels from elsewhere, a spasm, or a tear in a coronary artery.
Coronary thrombosis and myocardial infarction are sometimes used as synonyms, although this is technically inaccurate as the thrombosis refers to the blocking of blood vessels with a thrombus, while myocardial infarction refers to heart tissue death due to the consequent loss of blood flow to the heart. Due to extensive collateral circulation ...
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