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  2. Phage therapy - Wikipedia

    en.wikipedia.org/wiki/Phage_therapy

    Phage therapy is the use of bacteriophages to treat bacterial infections. Bacteriophage treatment offers a possible alternative to conventional antibiotic treatments for bacterial infection. [55] It is conceivable that, although bacteria can develop resistance to phages, the resistance might be easier to overcome than resistance to antibiotics.

  3. Center for Innovative Phage Applications and Therapeutics

    en.wikipedia.org/wiki/Center_for_Innovative...

    Phage therapy has gained recent attention in the United States as an alternative to standard antibiotic therapy. [ 5 ] [ 6 ] [ 7 ] It has been in practice for just over 100 years in countries such as Russia and Georgia , but due to the recent clinical attention of antibiotic resistance , Western countries have slowly been integrating phage ...

  4. Bacteriophage - Wikipedia

    en.wikipedia.org/wiki/Bacteriophage

    Structural model at atomic resolution of bacteriophage T4 [1] The structure of a typical myovirus bacteriophage Anatomy and infection cycle of bacteriophage T4.. A bacteriophage (/ b æ k ˈ t ɪər i oʊ f eɪ dʒ /), also known informally as a phage (/ ˈ f eɪ dʒ /), is a virus that infects and replicates within bacteria and archaea.

  5. Myoviridae - Wikipedia

    en.wikipedia.org/wiki/Myoviridae

    The tubular tail has helical symmetry and is 16-20 nm in diameter. It consists of a central tube, a contractile sheath, a collar, a base plate, six tail pins and six long fibers. It is similar to Tectiviridae, but differs in the fact that a myovirus' tail is permanent. Contractions of the tail require ATP. On contraction of the sheath, sheath ...

  6. Type VI secretion system - Wikipedia

    en.wikipedia.org/wiki/Type_VI_secretion_system

    The tubules consist of repeating units of the proteins TssA and TssB (VipA/VipB) arranged as a sheath around a tube built from stacked hexameric rings of the haemolysin co-regulated protein (Hcp). [ 12 ] [ 13 ] At the tip of the Hcp tube sits a trimer of the phage tail spike-like protein VgrG, which is in turn capped by a pointed PAAR domain ...

  7. Caudoviricetes - Wikipedia

    en.wikipedia.org/wiki/Caudoviricetes

    Bacteriophages occur in over 1100 bacterial or archaeal genera. [3] Over 6300 bacteriophages have been examined in the electron microscope since 1959. Of these, more than 96 percent have tails. Of the tailed phages, about 57 percent have long, noncontractile tails ("Siphoviridae"). Tailed phages appear to be monophyletic and are the oldest ...

  8. Restriction modification system - Wikipedia

    en.wikipedia.org/wiki/Restriction_modification...

    The RM system was first discovered by Salvatore Luria and Mary Human in 1952 and 1953. [1] [2] They found that a bacteriophage growing within an infected bacterium could be modified, so that upon their release and re-infection of a related bacterium the bacteriophage's growth is restricted (inhibited; also described by Luria in his autobiography on pages 45 and 99 in 1984). [3]

  9. Enterobacteria phage T2 - Wikipedia

    en.wikipedia.org/wiki/Enterobacteria_phage_T2

    Enterobacteria phage T2 is a virus that infects and kills E. coli.It is in the genus Tequatrovirus, and the family Myoviridae.Its genome consists of linear double-stranded DNA, with repeats at either end.