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Guided bone regeneration (GBR) and guided tissue regeneration (GTR) are dental surgical procedures that use barrier membranes to direct the growth of new bone and gingival tissue at sites with insufficient volumes or dimensions of bone or gingiva for proper function, esthetics or prosthetic restoration. Guided bone regeneration typically refers ...
PETTI Gustavo From Cagliari, Italy has been the first one to have had: "A new attachment: guided tissue regeneration using an amniotic membrane and fibrin glue" Publication: Petti G. (1989) “La rigenerazione parodontale guidata con membrana amniotica e colla di fibrina. (Guided periodontal regeneration with an amniotic membrane and fibrin glue).
Other considerations to bone healing include the concurrent use of bisphosphonate, and denosumab, smoking, diabetes, immunocompromise, and infection. [5] Another consideration is the risk of bone and soft tissue loss on the subsequent implant in the long-term. Socket preservation has been associated with a greater risk of marginal bone loss [6]
Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a derivative of PRP where autologous platelets and leukocytes are present in a complex fibrin matrix [1] [2] to accelerate the healing of soft and hard tissue [3] and is used as a tissue-engineering scaffold in oral and maxillofacial surgeries.
In 1994, Nowzari challenged membrane guided tissue regeneration through a series of research publications, showing that the membrane is actually a source of infection to the grafted site. [ 7 ] Research in the field of bone grafting has been focused on autogenous sources
A successful tissue regeneration relies on an appropriate source of stem progenitor cells, growth factors and scaffolds to control the development of the specific tissue. [19] The first component for tissue engineering is an appropriate source of progenitor/stem cells by using cells which are able to differentiate into the desired tissue component.
Incision on alveolar side near to bone leaving the periosteum intact. Removal of the frenal tissue and suturing the edges of the wound closely with resorbable sutures; Placing swabs over the wound; The patient is instructed to rinse twice daily with chlorhexidine mouthwash.
This strategy utilizes the guided bone regeneration treatment scheme, and is a safe method for bone prefabrication. These 'flap' methods of packing the bioreactor within fascia, or wrapping it in tissue is effective, though somewhat random due to the non-directed vascularization these methods incur.
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