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Ipglycermides are non-natural macrocyclic peptide (MCP) inhibitors of cofactor independent phosphoglycerate mutases (iPGM) discovered by the research laboratories of Dr. James Inglese of the National Institutes of Health and Prof. Hiroaki Suga of the University of Tokyo.
PeptiDream Announces License of PeptiDream's Peptide Discovery Platform System (PDPS) Technology to Bristol-Myers Squibb and Extension of the Macrocyclic Peptide Drug Discovery Alliance Between ...
“RFpeptides is a novel deep learning pipeline that enables the precise design of macrocyclic peptide binders for a wide range of therapeutic protein targets,” said Gaurav Bhardwaj, Ph.D., Assistant Professor, Department of Medicinal Chemistry at UW School of Pharmacy and Institute for Protein Design at the University of Washington, and Co ...
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Enlicitide chloride (INN; [1] previously known as MK-0616) is a macrocyclic peptide investigational drug who is being evaluated for the treatment of hypercholesterolaemia. It is a PCSK9 inhibitor. [2] Merck has launched a Phase 3 clinical trial to evaluate the efficacy and safety of MK-0616 in Adults With Hypercholesterolemia. [3] [4]
The promise of PeptiDream Inc's drug-discovery technology and its lucrative research-for-hire contracts have made it a darling of the Tokyo stock market. Now, those gains have made it a target for ...
Peptide therapeutics are peptides or polypeptides (oligomers or short polymers of amino acids) which are used to for the treatment of diseases.Naturally occurring peptides may serve as hormones, growth factors, neurotransmitters, ion channel ligands, and anti-infectives; peptide therapeutics mimic such functions.
Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. [1] It has been shown to inhibit methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci among other Gram-positive bacteria and mycoplasma. [2]