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Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure. [3] This may be done if the blood pressure is very high and resulting in symptoms , in certain types of heart failure , and during surgery to decrease bleeding . [ 3 ]
Most side effects are direct consequences of the vasodilation and the resultant low blood pressure. They include headache ("nitrate headache") resulting from the widening of blood vessels in the brain, reflex tachycardia (fast heart rate), flush, dizziness, nausea and vomiting. These effects usually subside after a few days if the treatment is ...
Sodium nitroprusside was previously the first-line choice due to its rapid onset, although now it is less commonly used due to side effects, drastic drops in blood pressure, and cyanide toxicity. Sodium nitroprusside is also contraindicated in patients with myocardial infarction, due to coronary steal. [9] It is again important that the blood ...
Sodium nitroprusside, a medicinally significant metal nitrosyl-pentacyanoferrate (Fe-III) compound, used to treat hypertension. [1] Metal nitrosyl complexes are complexes that contain nitric oxide, NO, bonded to a transition metal. [2] Many kinds of nitrosyl complexes are known, which vary both in structure and coligand.
Vasodilation plays a major role in immune system function. Wider blood vessels allow more blood containing immune cells and proteins to reach the infection site. Vasodilation occurs as part of the process of inflammation, which is caused by several factors including presence of a pathogen, injury to tissues or blood vessels, and immune ...
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine.NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development.
Nitric oxide is a reactive free radical mediating in neurotransmission, antimicrobial and antitumoral activities. [citation needed] In mice, the function of Nos2 in immunity against a number of viruses, bacteria, fungi, and parasites has been well characterized, whereas in humans the role of NOS2 has remained elusive and controversial. [7]
This process triggers VEGF-C transcription, resulting in the growth of lymph capillaries and blood vessels dilation, regulating salt-sensitive hypertension by lowering the blood pressure. [1] An increase in sodium ions concentration also facilitates the polymerisation of glycosaminoglycans, which helps the storage of sodium ions in the skin. [1 ...