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HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4. [7] Methylation of the estrogen-repressed gene HOXC10 in breast cancer determines resistance to aromatase inhibitors. This epigenetic reprogramming of HOXC10 is observed in endocrine-resistant breast cancer. [8]
Six Hox genes are dispersed in the genome of Caenorhabditis elegans, a roundworm. [10]: fig. 3 Hydra and Nematostella vectensis, both in the phylum Cnidaria, have a few Hox/ParaHox-like homeobox genes. [55] [11] Hox gene expression has also been studied in brachiopods, [56] annelids, [57] and a suite of molluscs. [58]
Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. [ 5 ] [ 6 ] [ 7 ] Hox-C6 expression is highest in the fallopian tube and ovary. [ 8 ] HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.
The mir-10 genes are found within the Hox gene clusters. In mammals there are four Hox gene clusters, these contain five genes encoding miRNAs (mir-10a, mir-10b, mir-196a-1, mir-196a-2 and mir-196b). The mir-10a gene is located upstream of Hoxb4 and the mir-10b gene is located upstream of Hoxd4. [9]
15424 Ensembl ENSG00000172789 ENSMUSG00000022485 UniProt Q00444 P32043 RefSeq (mRNA) NM_018953 NM_175730 RefSeq (protein) NP_061826 NP_783857 Location (UCSC) Chr 12: 54.03 – 54.04 Mb Chr 15: 102.88 – 102.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene. Function This gene belongs to the homeobox ...
The HOX gene contains four clusters (A, B, C, and D). The sense strand of the HOXA gene codes for proteins. Alternative names for HOXA11-AS lncRNA are: HOXA-AS5, HOXA11S, HOXA11-AS1, HOXA11AS, or NCRNA00076. This gene is 3,885 nucleotides long and resides at chromosome 7 (7p15.2) and is transcribed from an independent gene promoter.
Robb Krumlauf is an American developmental biologist.He is best known for researching the Hox family of transcription factors.He is most interested in understanding the role of the Hox genes in the hindbrain and their role in areas of animal development, such as craniofacial development.
15427 Ensembl ENSG00000180806 ENSMUSG00000036139 UniProt P31274 P09633 RefSeq (mRNA) NM_006897 NM_008272 RefSeq (protein) NP_008828 NP_032298 Location (UCSC) Chr 12: 53.99 – 54 Mb Chr 15: 102.88 – 102.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-C9 is a protein that in humans is encoded by the HOXC9 gene. Function This gene belongs to the homeobox ...