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  2. Olney's lesions - Wikipedia

    en.wikipedia.org/wiki/Olney's_lesions

    Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAT), is a form of brain damage consisting of selective death of neurons but not glia, observed in restricted brain regions of rats and certain other animal models exposed to large quantities of psychoactive drugs that inhibit the normal operation of the neuronal NMDA receptor.

  3. Neurotoxicity - Wikipedia

    en.wikipedia.org/wiki/Neurotoxicity

    As a final step, NOS is dephosphorylated yielding nitric oxide (NO), which accumulates in the brain, increasing its oxidative stress. There are several ROS, including superoxide, hydrogen peroxide and hydroxyl, all of which lead to neurotoxicity. Naturally, the body utilizes a defensive mechanism to diminish the fatal effects of the reactive ...

  4. Subacute combined degeneration of spinal cord - Wikipedia

    en.wikipedia.org/wiki/Subacute_combined...

    Administration of nitrous oxide anesthesia can precipitate subacute combined degeneration in people with subclinical vitamin B 12 deficiency, while chronic nitrous oxide exposure can cause it even in persons with normal B 12 levels. Posterior column dysfunction decreases vibratory sensation and proprioception (joint sense).

  5. Neurotoxin - Wikipedia

    en.wikipedia.org/wiki/Neurotoxin

    Common examples of neurotoxins include lead, [7] ethanol (drinking alcohol), [8] glutamate, [9] nitric oxide, [10] botulinum toxin (e.g. Botox), [11] tetanus toxin, [12] and tetrodotoxin. [6] Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive ...

  6. Recreational use of nitrous oxide - Wikipedia

    en.wikipedia.org/wiki/Recreational_use_of...

    Long-term or habitual use can lead to severe neurological damage. [3] Nitrous oxide is said to enhance the effects of psychedelics. [6] Since nitrous oxide can cause dizziness, dissociation, and temporary loss of motor control, it is unsafe to inhale while standing up. Safer use can involve inhalation while seated to decrease risks of injury by ...

  7. Chronic solvent-induced encephalopathy - Wikipedia

    en.wikipedia.org/wiki/Chronic_solvent-induced...

    Chronic solvent-induced encephalopathy (CSE) is a condition induced by long-term exposure to organic solvents, often—but not always—in the workplace, that lead to a wide variety of persisting sensorimotor polyneuropathies and neurobehavioral deficits even after solvent exposure has been removed.

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    Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!

  9. Cryoneurolysis - Wikipedia

    en.wikipedia.org/wiki/Cryoneurolysis

    Cryoneurolysis treatments that use nitrous oxide (boiling point of −88.5 °C) as the coolant fall in the range of an axonotmesis injury, or 2nd degree injury, according to the Sunderland classification system. [1] Treatments of the nerve in this temperature range are reversible, usually within a few months.