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2. B cell growth and differentiation factors - Wikipedia

   en.wikipedia.org/wiki/B_cell_growth_and...

   The most common simplified overview description of the B cell differentiation pathway involves the following steps: an antigen interacts with the corresponding surface membrane immunoglobulin after which the B cell begins expressing receptors for growth factors secreted by T cells (BCGFs and IL-2), after these factors bind, the lymphocytes ...

3. B cell - Wikipedia

   en.wikipedia.org/wiki/B_cell

   B cell activation: from immature B cell to plasma cell or memory B cell Basic B cell function: bind to an antigen, receive help from a cognate helper T cell, and differentiate into a plasma cell that secretes large numbers of antibodies. B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. [1]

4. Germinal center B-cell like diffuse large B-cell lymphoma

   en.wikipedia.org/wiki/Germinal_center_B-cell...

   B-cells form in the bone marrow and undergo gene rearrangement in order to develop B-cell receptors (BCRs) that bind to a specific antigen. Once activated by an antigen, B-cells proliferate and further differentiate into plasma cells and memory B-cells. [4] B-cells that have not encountered an antigen are called naive B cells.

5. Clone (B-cell) - Wikipedia

   en.wikipedia.org/wiki/Clone_(B-cell)

   The process of immunological B-cell maturation involves transformation from an undifferentiated B cell to one that secretes antibodies with particular specificity. [1] This differentiation and activation of the B cell occurs most rapidly after exposure to antigen by antigen-presenting cells in the reticuloendothelial system, and under modulation by T cells, and is closely intertwined with ...

6. B-cell activating factor - Wikipedia

   en.wikipedia.org/wiki/B-cell_activating_factor

   This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. [7] BAFF is a 285-amino acid long peptide glycoprotein which undergoes glycosylation at residue 124.

7. Cell growth - Wikipedia

   en.wikipedia.org/wiki/Cell_growth

   Cell growth refers to an increase in the total mass of a cell, including both cytoplasmic, nuclear and organelle volume. [1] Cell growth occurs when the overall rate of cellular biosynthesis (production of biomolecules or anabolism) is greater than the overall rate of cellular degradation (the destruction of biomolecules via the proteasome, lysosome or autophagy, or catabolism).

8. Bruton's tyrosine kinase - Wikipedia

   en.wikipedia.org/wiki/Bruton's_tyrosine_kinase

   Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The BTK gene is located on the X chromosome (Xq21.3-q22). [10] At least 400 mutations of the BTK gene have been identified. Of these, at least 212 are considered to be disease-causing mutations.

9. Regulatory B cell - Wikipedia

   en.wikipedia.org/wiki/Regulatory_B_cell

   Regulatory B cells (Bregs or B reg cells) represent a small population of B cells that participates in immunomodulation and in the suppression of immune responses. The population of Bregs can be further separated into different human or murine subsets such as B10 cells, marginal zone B cells, Br1 cells, GrB + B cells, CD9 + B cells, and even some plasmablasts or plasma cells.