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HIV is an RNA virus, so it can not be integrated into the DNA in the nucleus of the human cell unless it is first "reverse" transcribed into DNA. Since the conversion of RNA to DNA is not naturally done in the mammalian cell, it is performed by a viral protein, reverse transcriptase, which makes it a selective target for inhibition. NRTIs are ...
Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS. It is used as part of a combination regimen. Zalcitabine appears less potent than some other nucleoside RTIs, has an inconvenient three-times daily frequency and is associated with serious adverse events.
HIV/AIDS is a terminal illness, as there is currently no cure, nor an effective HIV vaccine. Treatment consists of highly active antiretroviral therapy (ART), which slows progression of the disease. [153] As of 2022, 39 million people globally were living with HIV, and 29.8 million people were accessing ART. [154]
An improved knowledge of the action of reverse transcriptase has led to better nucleoside analogues to treat HIV infections. One of these drugs, lamivudine, has been approved to treat hepatitis B, which uses reverse transcriptase as part of its replication process. Researchers have gone further and developed inhibitors that do not look like ...
Naturally-occurring HGH is released by your pituitary gland, ... In adults, GH therapy has been FDA-approved to treat GHD and HIV-related muscle loss. What causes growth hormone deficiency?
HIV-2 carries a slightly lower risk of transmission than HIV-1 and infection tends to progress more slowly to AIDS. [7] In common usage HIV usually implies HIV-1. [8] HIV-1 protease is one of the best known aspartic proteases, and an attractive target for the treatment of AIDS. [9]
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