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Pembrolizumab, sold under the brand name Keytruda, is a humanized antibody, more specifically a PD-1 Inhibitor, used in cancer immunotherapy that treats melanoma, lung cancer, head and neck cancer, Hodgkin lymphoma, stomach cancer, cervical cancer, and certain types of breast cancer. [12] [14] [15] [16] It is administered by slow intravenous ...
Keytruda slashed the risk of death by 21% over placebo in hepatocellular carcinoma patients in Asia who had previously received sorafenib. Merck's Keytruda also beat placebo at shrinking tumors ...
Mice with the CTLA-4 gene removed (e.g. CTLA-4 knockout) develop severe autoimmune disease, with diffuse infiltration of T cells in multiple organs and fatal enterocolitis. [2] Immune checkpoint inhibitor colitis is typically characterized by either diffuse mucosal inflammation or focal active colitis with patchy crypt abscesses. [4]
This holds promise for combining check point inhibitor therapy with immunosuppressive drugs to achieve anti-cancer effects with less toxicity. Studies are beginning to show that intrinsic factors, such as species of the genus Bacteroides that inhabit the gut microbiome [ 30 ] prospectively modify risk of developing immune related adverse events.
Merck & Co Inc (NYSE: MRK) has announced that the Phase 3 KEYNOTE-091 trial, investigating Keytruda, met one of its dual primary endpoints in NSCLC patients following surgical resection regardless ...
Fatty liver disease is known as a “silent disease” as it has few symptoms. In fact, you might have fatty liver disease and not even know it. You may not experience any symptoms at all until it ...
Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
Dr. Clarke notes that mild liver damage usually starts with loss of appetite and fatigue, while more acute or severe liver damage has other symptoms. If you ever notice that you have jaundice, see ...
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