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In 1997, ondansetron was the subject of a meta-analysis case study. Researchers examined 84 trials, with 11,980 people receiving ondansetron, published between 1991 and September 1996. Intravenous ondansetron 4 mg versus placebo was investigated in 16 reports and three further reports which had been duplicated a total of six times.
Ondansetron: Carbazole derivative 5-HT 3 receptor antagonist and weak 5-HT 4 antagonist 3.9 hours CYP1A1/2, CYP2D6, CYP 3A3/4/5: 150 μg/kg Granisetron: Indazole: 5-HT 3 receptor antagonist 9–11.6 hours CYP3A3/4/5: 10 μg/kg Dolasetron: Indole: 5-HT 3 receptor antagonist 7–9 hours CYP 3A3/4/5, CYP2D6: 600 – 3000 μg/kg Palonosetron ...
[4] The term "anticholinergic" is typically used to refer to antimuscarinics which competitively inhibit the binding of ACh to muscarinic acetylcholine receptors; such agents do not antagonize the binding at nicotinic acetylcholine receptors at the neuromuscular junction, although the term is sometimes used to refer to agents which do so. [3] [5]
Ondansetron; Palonosetron; Tropisetron; Other 5-HT 3 antagonists have been considered for use in the treatment of irritable bowel syndrome: Alosetron; Cilansetron; Also, the antidepressant mirtazapine acts as a 5-HT 3 antagonist.
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Patients do receive antiemetic medications, such as Ondansetron and Dexamethasone, during the surgical procedure if the patient is at risk for it. [1] [6] Along with PONV, there are numerous complications that can happen with many different organ systems, the most threatening of which involves the respiratory system, and cardiovascular system. [5]
Usually, laxatives are a consideration after lifestyle changes to relieve constipation, like taking up a regular exercise routine and increasing fiber or water intake, have already been tried.
As America's population ages, rates of Alzheimer's disease diagnoses are rising. One consequence of the degenerative brain disorder is wandering, which can be dangerous—and sometimes deadly ...
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