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Disadvantages: Sildenafil takes longer to work after a large, high-fat meal and can’t be taken more than once a day, making it less than ideal for twice-a-day (or more) intimacy. Sildenafil Pros
Here’s a fun fact, actually: According to Johnson, the main active ingredients of erectile dysfunction medications Cialis and Viagra—tadalafil and sildenafil—work by lowering blood pressure.
Some reports say that since Viagra can widen blood vessels, it can increase blood flow through the heart, permitting more oxygen to the lungs and improving oxygen supply to the rest of the body.
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [ 4 ] [ 8 ] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon . [ 9 ]
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Viagra (or sildenafil) lasts three to five hours after it’s consumed. Cialis (tadalafil) has a half-life of 17.5 hours, meaning this drug lasts up to 36 hours after it’s consumed.
In clinical trials of Viagra, more than 82 percent of men with ED reported an improvement in their climaxes after using Viagra at a dosage of 100mg (the highest dosage prescribed for ED).
Older than 45 years old - 19.6% (mild), 5.9% (severe) Venous leakage: 7.84% (of 67 patients) [ 1 ] Venous leak , also called venogenic erectile dysfunction and penile venous insufficiency , is one category of vasculogenic impotence — a cause of erectile dysfunction in males. [ 2 ]
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