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  2. Zygosity - Wikipedia

    en.wikipedia.org/wiki/Zygosity

    Most eukaryotes have two matching sets of chromosomes; that is, they are diploid. Diploid organisms have the same loci on each of their two sets of homologous chromosomes except that the sequences at these loci may differ between the two chromosomes in a matching pair and that a few chromosomes may be mismatched as part of a chromosomal sex ...

  3. Inbreeding - Wikipedia

    en.wikipedia.org/wiki/Inbreeding

    Inbreeding results in homozygosity which can increase the chances of offspring being affected by recessive traits. [3] In extreme cases, this usually leads to at least temporarily decreased biological fitness of a population [ 4 ] [ 5 ] (called inbreeding depression ), which is its ability to survive and reproduce.

  4. Runs of homozygosity - Wikipedia

    en.wikipedia.org/wiki/Runs_of_Homozygosity

    Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring. [ 1 ] The potential of predicting or estimating individual autozygosity for a subpopulation is the proportion of the autosomal genome above a specified length, termed F ...

  5. Genetic purging - Wikipedia

    en.wikipedia.org/wiki/Genetic_purging

    Genetic purging is the increased pressure of natural selection against deleterious alleles prompted by inbreeding. [1]Purging occurs because deleterious alleles tend to be recessive, which means that they only express all their harmful effects when they are present in the two copies of the individual (i.e., in homozygosis).

  6. Human genome - Wikipedia

    en.wikipedia.org/wiki/Human_genome

    The human genome is a complete set of nucleic acid sequences for humans, encoded as the DNA within each of the 24 distinct chromosomes in the cell nucleus. A small DNA molecule is found within individual mitochondria. These are usually treated separately as the nuclear genome and the mitochondrial genome. [1]

  7. Human genetics - Wikipedia

    en.wikipedia.org/wiki/Human_genetics

    The human genome is the total collection of genes in a human being contained in the human chromosome, composed of over three billion nucleotides. [2] In April 2003, the Human Genome Project was able to sequence all the DNA in the human genome, and to discover that the human genome was composed of around 20,000 protein coding genes.

  8. Genetic load - Wikipedia

    en.wikipedia.org/wiki/Genetic_load

    In the short run, an increase in inbreeding increases the probability with which offspring get two copies of a recessive deleterious alleles, lowering fitnesses via inbreeding depression. [22] In a species that habitually inbreeds, e.g. through self-fertilization , a proportion of recessive deleterious alleles can be purged .

  9. F-statistics - Wikipedia

    en.wikipedia.org/wiki/F-statistics

    F IT is the inbreeding coefficient of an individual (I) relative to the total (T) population, as above; F IS is the inbreeding coefficient of an individual (I) relative to the subpopulation (S), using the above for subpopulations and averaging them; and F ST is the effect of subpopulations (S) compared to the total population (T), and is ...