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  2. Gangliosidosis - Wikipedia

    en.wikipedia.org/wiki/Gangliosidosis

    Gangliosidosis contains different types of lipid storage disorders [1] caused by the accumulation of lipids known as gangliosides. There are two distinct genetic causes of the disease. There are two distinct genetic causes of the disease.

  3. GM2 gangliosidoses - Wikipedia

    en.wikipedia.org/wiki/GM2_gangliosidoses

    GM2-gangliosidosis, AB variant is a rare, autosomal recessive metabolic disorder that causes progressive destruction of nerve cells in the brain and spinal cord. Mutations in the GM2A gene cause AB variant. The GM2A gene provides instructions for making a protein called the GM2 activator.

  4. GM1 gangliosidoses - Wikipedia

    en.wikipedia.org/wiki/GM1_gangliosidoses

    The GM1 gangliosidoses, usually shortened to GM1, are gangliosidoses caused by mutation in the GLB1 gene resulting in a deficiency of beta-galactosidase.The deficiency causes abnormal storage of acidic lipid materials in cells of the central and peripheral nervous systems, but particularly in the nerve cells, resulting in progressive neurodegeneration.

  5. What Is Heart Disease? Everything You Need to Know - AOL

    www.aol.com/heart-disease-everything-know...

    Heart disease is a type of cardiovascular disease that affects the heart’s structure and function. Several different heart conditions fall under the umbrella term for heart disease.

  6. Ganglioside - Wikipedia

    en.wikipedia.org/wiki/Ganglioside

    Mutations in genes coding for these enzymes leads to the accumulation of partially broken down gangliosides in lysosomes, which results in a group of diseases called gangliosidosis. For example, the fatal Tay–Sachs disease arises as a genetic defect which leads to no functional hexosaminidase A produced, causing GM2 to accumulate in lysosomes.

  7. GM 2 gangliosidosis - Wikipedia

    en.wikipedia.org/wiki/GM_2_gangliosidosis

    GM 2 gangliosidosis refers to several similar genetic disorders: Tay–Sachs disease; Sandhoff disease; GM2-gangliosidosis, AB variant

  8. GM1 - Wikipedia

    en.wikipedia.org/wiki/GM1

    GM1 gangliosidosis are inherited disorders that progressively destroy neurons in the brain and spinal cord as GM1 accumulates. Without treatment, this results in developmental decline and muscle weakness, eventually leading to severe retardation and death.

  9. Sphingolipidoses - Wikipedia

    en.wikipedia.org/wiki/Sphingolipidoses

    Sphingolipidoses are a class of lipid storage disorders or degenerative storage disorders caused by deficiency of an enzyme that is required for the catabolism of lipids that contain ceramide, [1] also relating to sphingolipid metabolism.