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JUPITER was a randomized double-blind placebo-controlled study investigating the use of rosuvastatin in the primary prevention of cardiovascular disease.The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP).
A systematic review concluded that while clinical trial meta-analyses underestimate the rate of muscle pain associated with statin use, the rates of rhabdomyolysis are still "reassuringly low" and similar to those seen in clinical trials (about 1–2 per 10,000 person years). [74]
Tell Your Children: The Truth About Marijuana, Mental Illness and Violence is a 2019 book by Alex Berenson.In it, Berenson makes claims that cannabis use directly causes psychosis and violence, claims denounced as alarmist and inaccurate by many in the scientific and medical communities.
Statins are a competitive antagonists of HMG CoA, as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). [5] By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway.
In his books, newsletter, and interviews, Sinatra advocated treatment approaches that combine conventional medical therapies with nutritional and mind-body therapies that he thought enhance the body’s natural bioenergetics and heal the heart. He promoted his ideas of five specific pillars of cardiac health:
Each chapter deals with a specific aspect of bad science, often to illustrate a wider point. For example, the chapter on homeopathy becomes the point where he explains the placebo effect, regression to the mean (that is, the natural cycle of the disease), placebo-controlled trials (including the need for randomisation and double blinding), meta-analyses like the Cochrane Collaboration and ...
The Hungry Brain: Outsmarting the Instincts That Make Us Overeat is a 2017 non-fiction book by Stephan J. Guyenet. Guyenet describes the mechanisms by which the brain regulates diet. Guyenet describes the mechanisms by which the brain regulates diet.
MediaWiki2LaTeX provides a softcopy conversion service to pdf and other formats. It remains under active support and may be used online or installed locally. Pedia Press offer final tidying and ordering of print-on-demand bound copies in (approximately) A5 format. For help with downloading a single Wikipedia page as a PDF, see Help:Download as PDF.