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Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. [1] Using organelles (particularly the rough endoplasmic reticulum ), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers. [ 2 ]
Photoaging or photoageing [1] (also known as "dermatoheliosis" [2]) is a term used for the characteristic changes to skin induced by chronic UVA and UVB exposure. [ 3 ] : 29 Tretinoin is the best studied retinoid in the treatment of photoaging.
Photorejuvenation is a skin treatment that uses lasers, intense pulsed light, or photodynamic therapy to treat skin conditions and remove effects of photoaging such as wrinkles, spots, and textures. The process induces controlled wounds to the skin. This prompts the skin to heal itself, by creating new cells.
Burn scar contracture is the tightening of the skin after a second or third degree burn. When skin is burned, the surrounding skin begins to pull together, resulting in a contracture. It needs to be treated as soon as possible because the scar can result in restriction of movement around the injured area. This is mediated by myofibroblasts. [1]
Often combined with radiofrequency (RF microneedling), they tighten and rejuvenate the skin. LED light-therapy devices, such as LightStim, use light wavelengths to penetrate the skin.
This type of connective tissue is found mostly in the reticular layer (or deep layer) of the dermis. [3] It is also in the sclera and in the deeper skin layers. Due to high portions of collagenous fibers, dense irregular connective tissue provides strength, making the skin resistant to tearing by stretching forces from different directions.
Fibroblast activity results in extracellular matrix deposition and dermal thickening. Antioxidants introduced through the procedure hydrate and decrease inflammation in the skin, reversing photo damage, while protecting lipid membranes, collagen fibers, and enzyme systems.
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