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Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. The racemization process can occur in vivo.
Additionally, informed consent became a participation requirement and rules were put into place. This regulation was influenced by the results of 1950 use of thalidomide in Western Europe for pregnant women. They were prescribed the sedative thalidomide, which was inaccurately marketed as a morning sickness treatment. Women gave birth to more ...
David Leslie Mason OBE (born 15 March 1939) is a London art dealer and Thalidomide parent activist. He is the father of a daughter, Louise, disabled by thalidomide. Mason was educated at Highgate School, where he studied under Kyffin Williams. [1]
Alexander Leslie Florence, also called Leslie Florence (1927 – 26 March 2018) was a Scottish general practitioner, known for his letter on his observations of neurological side effects of thalidomide, published on 31 December 1960 in the British Medical Journal, and noticed by Frances Kelsey. [1] [2] [3]
Thalidomide had been developed by Grunenthal with whom, in July 1957, DCBL signed a sixteen-year contract to market the drug. DCBL ordered 6,000 tablets for clinical trial and 500 grammes of pure substance for animal experiments and formulation. Thalidomide was marketed in the United Kingdom under the name Distaval, beginning on 14 April 1958.
On Giant's Shoulders is a 1979 BBC television film about the early life of thalidomide victim Terry Wiles, with Wiles playing himself. The drama also starred Bryan Pringle and Judi Dench and won an Emmy Award in 1980. [1] [2]
Michaelina "Mikey" Argy [1] MBE (born 1962) is an English thalidomide survivor and activist. [2] [3] She is a past chair of the National Advisory Committee of the Thalidomide Trust, the organisation through which British thalidomide survivors receive financial support, [1] and is still involved in the media activities of the trust.