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The British Thalidomide Children's Trust was set up in 1973 as part of a £20 million legal settlement between Distillers Company and 429 children with thalidomide-related disabilities. In 1997, Diageo (formed by a merger between Grand Metropolitan and Guinness, who had taken over Distillers in 1990) made a long-term financial commitment to ...
Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. The racemization process can occur in vivo.
Lorraine Mercer MBE is a British thalidomide survivor, painter, lace maker, and carriage driver with the RDA. Mercer was a representative of the global thalidomide community as a bearer of the Olympic Torch in 2012 for her country. [1] [2] Her chariot was adapted to carry the Olympic torch safely above her head away from the oxygen she needs.
Thalidomide had only been tested on rodents, as was usual practice at the time. [ 13 ] In the UK, the British pharmaceutical company The Distillers Company (Biochemicals) Ltd, a subsidiary of Distillers Co. Ltd. (which became part of Diageo plc in 1997) marketed thalidomide under the brand name Distaval as a remedy for morning sickness ...
Alexander Leslie Florence, also called Leslie Florence (1927 – 26 March 2018) was a Scottish general practitioner, known for his letter on his observations of neurological side effects of thalidomide, published on 31 December 1960 in the British Medical Journal, and noticed by Frances Kelsey. [1] [2] [3]
Distillers increased the offer to £5m and then £20m, which was accepted. The settlement is credited with transforming the lives of British thalidomide victims. The Thalidomide Trust is now largely funded by Diageo, who bought Distillers and its assets and liabilities. Mason's book Thalidomide: My Fight was published in 1976.
On the history of the Contergan (thalidomide) catastrophe in the light of drug legislation, Dtsch Med Wochenschr. 2001 October 19;126(42):1183-6. Shah RR., Thalidomide, drug safety and early drug regulation in the UK, Adverse Drug React Toxicol Rev. 2001 Dec;20(4):199-255.
Following World War II, DCBL purchased the facility from the UK Government. [14] Distillers was also responsible for the manufacture of the drug Thalidomide in the United Kingdom. [15] Thalidomide had been developed by Grunenthal with whom, in July 1957, DCBL signed a sixteen