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This dose–response meta‐analysis demonstrates that combined intake of omega‐3 fatty acids near linearly lowers triglyceride and non‐high‐density lipoprotein cholesterol. Triglyceride‐lowering effects might provide supportive evidence for omega‐3 fatty acid intake to prevent cardiovascular events.
Omega-3s from fish and fish oil have been recommended by the American Heart Association (AHA) for the past 20 years to reduce cardiovascular events, like heart attack or stroke, in people who already have cardiovascular disease (CVD).
Although no data have suggested that the low-density lipoprotein-cholesterol (LDL-C) increases associated with some omega-3 fatty acid formulations lead to adverse outcomes, these elevations in LDL-C levels may compromise the achievement of lipid targets.
Elevated plasma triglycerides are the result of an excess of triglyceride-rich lipoproteins of several different types, most commonly very-low-density lipoproteins (VLDLs) but also intermediate-density lipoproteins (or VLDL remnants), chylomicrons, or chylomicron remnants.
Epidemiological, genomic, and population-based interventions have shown that elevated low-density lipoprotein cholesterol (LDL-C) is one of the major risk factors, a “pathogenicity”, for atherosclerotic cardiovascular disease (ASCVD).
Omega-3 also was associated with increased LDL among CVD patients (2.10 mg/dL 95% CI: 1.00, 3.20, p = 0.0002). We conclude that omega-3 fatty acids may be associated with lower inflammatory...
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) may beneficially influence the risk of cardiovascular disease (CVD), especially in the secondary prevention of CVD. Recent findings from randomized controlled trials and meta-analyses led to a class IIa recommendation by the American Heart Association for dietary supplementation with n -3 PUFAs in ...
2 Altmetric. Explore all metrics. Abstract. Purpose of Review. Omega-3 fatty acids (n-3 FA) lower triglycerides, have anti-inflammatory properties, and improve metabolism. Clinical evidence of cardiovascular benefit with omega-3 fatty acids is mixed.
In this updated meta-analysis of 38 randomized controlled trials, omega-3 FAs were associated with reducing cardiovascular mortality and other cardiovascular outcomes. A meta-analysis of EPA trials showed greater relative risk reductions in cardiovascular outcomes than those of EPA+DHA.
The overall effect on blood lipids for marine omega-3 EPA and DHA seems to be protective due to overall improvements in LDL particle size and density as well as reductions in VLDL, TGs, and increases in HDL.