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Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine.Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kidney injury.
Do you sometimes have severe, unexplained pain in your joints, particularly in your big toe, ankle, or knee? The post Managing Out-of-Control Chronic Gout: Going Beyond Oral Treatments appeared ...
Meat and meat products contain purines. ... Colchicine can also help manage pain from gout when taken immediately after symptoms occur, and corticosteroids can help with inflammation, swelling and ...
During a gout flare-up, you have acute gout symptoms, such as intense pain and swelling in an affected joint. Intercritical gout. This is the time between gout flares when you have no symptoms ...
Gout occurs more commonly in those who regularly drink beer or sugar-sweetened beverages; eat foods that are high in purines such as liver, shellfish, or anchovies; or are overweight. [1] [3] Diagnosis of gout may be confirmed by the presence of crystals in the joint fluid or in a deposit outside the joint. [1]
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [4] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
Although foods such as meat and seafood can elevate serum urate levels, genetic variation is a much greater contributor to high serum urate. [26] [27] A proportion of people have mutations in the urate transport proteins responsible for the excretion of uric acid by the kidneys.
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