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Amisulpride (Solian) – approved in low doses as a monotherapy for persistent depression and major depressive disorder [10] Levosulpiride – approved in low doses for major depressive disorder [11] Lumateperone (Caplyta) – approved as a monotherapy for bipolar depression; Lurasidone (Latuda) – approved as a monotherapy for bipolar depression
The FDA granted the approval of Jatenzo to Clarus Therapeutics. [22] [51] In March 2022, testosterone undecanoate (Tlando) was approved for medical use in the United States. [5] In July 2022, Kyzatrex, an oral testosterone undecanoate capsule, was approved for medical use in the United States.
A meta-analysis examined the effectiveness of psychotherapy for depression across ages from younger than 13 years to older than 75 years. It summarizes results from 366 trials included 36,702 patients. It found that the best results were for young adults, with an average effect size of g=.98 (95% CI, 0.79–1.16). [10]
Auvelity, from Axsome Therapeutics, marks the first drug with a different mechanism of action approved for treating depression in 60 years. In clinical trials, participants reported…
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Paroxetine was the first drug to be FDA-approved for this disorder. Its efficacy is considered beneficial, although not everyone responds favorably to the drug. Sertraline and fluvoxamine extended-release were later approved for it as well, while escitalopram is used off-label with acceptable efficiency.
The Food and Drug Administration (FDA) recently approved the nasal spray Spravato for the treatment of major depression in people who have not responded to at least two oral antidepressants ...
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