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Chloroquine retinopathy is a form of toxic retinopathy (damage of the retina) caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. [3]
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A World Health Organization infographic that states that hydroxychloroquine does not prevent illness or death from COVID-19. Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases. [64] Chloroquine, along with hydroxychloroquine, was an early experimental treatment for COVID-19. [65]
Hydroxychloroquine increases [40] lysosomal pH in antigen-presenting cells [19] by two mechanisms: As a weak base, it is a proton acceptor and via this chemical interaction, its accumulation in lysozymes raises the intralysosomal pH, but this mechanism does not fully account for the effect of hydroxychloroquine on pH.
Hydroxychloroquine (Plaquenil) is another option and is generally considered safer than methotrexate. However, these prescribed drugs have a range of side effects such as nausea , loss of appetite , dizziness , hair loss , stomach aches/cramps , headache , liver toxicity and increased risk of infections .
Alport syndrome is a genetic disorder [1] affecting around 1 in 5,000–10,000 children, [2] characterized by glomerulonephritis, end-stage kidney disease, and hearing loss. [3] Alport syndrome can also affect the eyes, though the changes do not usually affect vision, except when changes to the lens occur in later life. Blood in urine is universal.
Dual sensory loss is the simultaneous loss of two senses. Research has shown that 6% of non-institutionalized older adults had a dual sensory impairment, and 70% of severely visually impaired older adults additionally suffered from significant hearing loss. [7] Vision and hearing loss both interfere with the interpretation and comprehension of ...
The results of the analyser identify the type of vision defect. Therefore, it provides information regarding the location of any disease processes or lesion(s) throughout the visual pathway . This guides and contributes to the diagnosis of the condition affecting the patient's vision.
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