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  2. Proteins produced and secreted by the liver - Wikipedia

    en.wikipedia.org/wiki/Proteins_produced_and...

    Inhibitors of coagulation: Inactivate an enormous variety of proteinases α2-macroglobulin; α1-antitrypsin; Antithrombin III; Protein S; Protein C; Fibrinolysis: Breakdown of fibrin clots Plasminogen; Inhibitors of fibrinolysis. α2-antiplasmin; Complement components C1-9, complement component 3 (C3)

  3. Antihemorrhagic - Wikipedia

    en.wikipedia.org/wiki/Antihemorrhagic

    The stick is applied directly to the bleeding site. The high ionic strength promotes flocculation of the blood, and the astringent chemical causes local vasoconstriction. Before safety razors were invented, a styptic pencil was a standard part of a shaving kit and was used to seal shaving cuts. [ 13 ]

  4. List of cytochrome P450 modulators - Wikipedia

    en.wikipedia.org/wiki/List_of_cytochrome_P450...

    1 List of Herbal cytochrome P450 Inhibitors and Inducers. 2 See also. 3 Sources. ... Certain foods (e.g., broccoli, cauliflower, brussels sprouts, chargrilled meat)

  5. Danicopan - Wikipedia

    en.wikipedia.org/wiki/Danicopan

    Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. [6] [7] It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells.

  6. C1-inhibitor - Wikipedia

    en.wikipedia.org/wiki/C1-inhibitor

    C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. [5] Its main function is the inhibition of the complement system to prevent spontaneous activation but also as the major regulator of the contact system.

  7. Gastrointestinal bleeding - Wikipedia

    en.wikipedia.org/wiki/Gastrointestinal_bleeding

    Despite treatment, re-bleeding occurs in about 7–16% of those with upper GI bleeding. [3] In those with esophageal varices, bleeding occurs in about 5–15% a year and if they have bled once, there is a higher risk of further bleeding within six weeks. [13] Testing and treating H. pylori if found can prevent re-bleeding in those with peptic ...

  8. C4b-binding protein - Wikipedia

    en.wikipedia.org/wiki/C4b-binding_protein

    C4b-binding protein (C4BP) is a protein complex involved in the complement system where it acts as inhibitor. C4BP has an octopus-like structure with a central stalk and seven branching alpha-chains. C4BP has an octopus-like structure with a central stalk and seven branching alpha-chains.

  9. CYP3A4 - Wikipedia

    en.wikipedia.org/wiki/CYP3A4

    a Moderate inhibitor causes at least a 2-fold increase in the plasma AUC values, or 50–80% decrease in clearance. [39] a Weak inhibitor causes at least a 1.25-fold but less than 2-fold increase in the plasma AUC values, or 20–50% decrease in clearance. [39] The inhibitors of CYP3A4 are the following substances.