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Disulfiram is used as a second-line treatment, behind acamprosate and naltrexone, for alcohol dependence. [7]Under normal metabolism, alcohol is broken down in the liver by the enzyme alcohol dehydrogenase to acetaldehyde, which is then converted by the enzyme acetaldehyde dehydrogenase to a harmless acetic acid derivative (acetyl coenzyme A).
Acamprosate, sold under the brand name Campral, is a medication which reduces alcoholism cravings. [ 1 ] [ 5 ] It is thought to stabilize chemical signaling in the brain that would otherwise be disrupted by alcohol withdrawal . [ 6 ]
A disulfiram-like drug is a drug that causes an adverse reaction to alcohol leading to nausea, vomiting, flushing, dizziness, throbbing headache, chest and abdominal discomfort, and general hangover-like symptoms among others.
In the United States there are four approved medications for alcoholism: acamprosate, two methods of using naltrexone and disulfiram. [160] Acamprosate may stabilise the brain chemistry that is altered due to alcohol dependence via antagonising the actions of glutamate, a neurotransmitter which is hyperactive in the post-withdrawal phase. [161]
ATC code N07 Other nervous system drugs is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
[5] [6] It may also be characterized as intolerance causing hangover symptoms similar to the "disulfiram-like reaction" of aldehyde dehydrogenase deficiency or chronic fatigue syndrome. [ 7 ] [ 8 ] [ 9 ] Severe pain after drinking alcohol may indicate a more serious underlying condition.
Acamprosate may work better than naltrexone for eliminating alcohol abuse, while naltrexone may decrease the desire for alcohol to a greater extent. [ 26 ] A method pioneered by scientist John David Sinclair (dubbed commercially the “Sinclair Method”) advocates for “pharmacological extinction” of problem drinking behavior by ...
Disulfiram-like drugs that produce sensitivity to the toxic effects of alcohol (drug). Mostly acetaldehyde dehydrogenase inhibitors. Subcategories.
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261