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n/a Ensembl ENSG00000184033 n/a UniProt P78358 n/a RefSeq (mRNA) NM_001327 n/a RefSeq (protein) NP_640343 NP_001318 n/a Location (UCSC) Chr X: 154.62 – 154.62 Mb n/a PubMed search n/a Wikidata View/Edit Human Cancer/testis antigen 1 also known as LAGE2 or LAGE2B is a protein that in humans is encoded by the CTAG1B gene. It is most often referenced by its alias NY-ESO-1. Cancer/Testis Antigen ...
Cancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a locus of immune activation.
Testis-expressed protein 14 is a protein in humans encoded by the TEX14 gene, and is 1497 amino acids in length. [5] TEX14 plays a vital role in the formation of germ cells, as it is an essential component of the mammalian germ cell interphase bridge. [6] An orthologue of TEX14 exists in other mammals, also called TEX14.
The nuclear protein in testis gene (i.e. NUTM1 gene) encodes (i.e. directs the synthesis of) a 1,132-amino acid protein termed NUT [1] that is expressed almost exclusively in the testes, ovaries, [2] and ciliary ganglion (i.e. a parasympathetic ganglion of nerve cells located just behind the eye). [3]
NUT carcinoma (NC; formerly NUT midline carcinoma (NMC)) is a rare genetically defined, very aggressive squamous cell epithelial cancer that usually arises in the midline of the body and is characterized by a chromosomal rearrangement in the nuclear protein in testis gene (i.e. NUTM1 gene). [2]
ETS Related Molecule or ERM transcription factor is needed for maintenance of the spermatogonial stem cells in the adult testis; transferrin, a blood plasma protein for iron ion delivery [11] testicular ceruloplasmin, a ceruloplasmin-like protein which is immunologically similar to serum ceruloplasmin. [12]
Cancer/testis antigen family 45, member A5 is a protein in humans that is encoded by the CT45A5 gene. [3] This gene represents one of a cluster of six similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other
Two transcript variants encoding the same protein have been found for this gene. [ 6 ] The use of three different mouse models (Brdt knock-out mice, mice expressing a non-functional Brdt and mice expressing a mutated Brdt lacking its first bromodomain) showed that Brdt drives a meiotic and post-meiotic gene expression program.