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Rhabdomyolysis (shortened as rhabdo) is a condition in which damaged skeletal muscle breaks down rapidly, often due to high intensity exercise over a short period. [6] [4] [5] Symptoms may include muscle pains, weakness, vomiting, and confusion. [3] [4] There may be tea-colored urine or an irregular heartbeat.
These systemic effects are caused by a traumatic rhabdomyolysis. As muscle cells die, they absorb sodium, water, and calcium; the rhabdomyolysis releases potassium, myoglobin, phosphate, thromboplastin, creatine, and creatine kinase. [citation needed] Crush syndrome can directly come from compartment syndrome, if the injury is left untreated. [8]
Exertional rhabdomyolysis (ER) is the breakdown of muscle from extreme physical exertion. It is one of many types of rhabdomyolysis that can occur, and because of this, the exact prevalence and incidence are unclear.
The pressure keeps rising due to the non-compliant fascia in the compartment. [5] This cycle can cause tissue ischemia, a lack of oxygen, and necrosis, or tissue death. [6] [5] [43] Paresthesia, or tingling, can start as early as 30 minutes after tissue ischemia begins. [45] Permanent damage can occur 12 hours after the injury starts. [45]
Rhabdomyolysis (rapid breakdown of damaged or injured skeletal muscle) Elevated creatine kinase levels. Dry, thinning skin and decreased production of sebum (an oily substance that products your skin)
Crush syndrome is a systemic result of skeletal muscle injury and breakdown and subsequent release of cell contents. [4] The severity of crush syndrome is dependent on the duration and magnitude of the crush injury as well as the bulk of muscle affected.
Highly elevated blood myoglobin levels from muscle breakdown (rhabdomyolysis) can result in kidney damage, therefore aggressive intravenous hydration with diuresis may be required. When recognized early NMS can be successfully managed; however, up to 10% of cases can be fatal.
Myoglobinuria pathophysiology consists of a series of metabolic actions in which damage to muscle cells affect calcium mechanisms, thereby increasing free ionized calcium in the cytoplasm of the myocytes (concurrently decreasing free ionized calcium in the bloodstream). This, in turn, affects several intracellular enzymes that are calcium ...