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Isoprenaline was discovered in 1940 [5] and was developed in the 1940s. [7] It was first approved for medical use in 1947 in the United States. [15] Isoprenaline was one of the first synthetic sympathomimetic amines, was the first selective β-adrenergic receptor agonist, and was the first major sympathomimetic agent devoid of pressor effects ...
The mechanisms of sympathomimetic drugs can be direct-acting (direct interaction between drug and receptor), such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting (interaction not between drug and receptor), such as MAOIs, COMT inhibitors, release stimulants, and reuptake inhibitors that increase the levels of endogenous catecholamines.
Prior to their discovery, the non-selective beta-agonist isoprenaline was used. The aim of the drug development through the years has been to minimise side effects, achieve selectivity and longer duration of action. The mechanism of action is well understood and has facilitated the development.
Pharmaceutical compound Poppers A selection of over-the-counter poppers on display Clinical data Other names popper, poppe Routes of administration Inhalation Drug class Vasodilator Legal status Legal status AU: S4 (Prescription only) in general; some exceptions Elsewhere, usually available OTC Pharmacokinetic data Bioavailability When inhaled, Amyl nitrite: unknown Isopropyl nitrite: 43% ...
Clorprenaline (INN Tooltip International Nonproprietary Name, USAN Tooltip United States Adopted Name, BAN Tooltip British Approved Name), also known as isoprophenamine and known as clorprenaline hydrochloride (USAN Tooltip United States Adopted Name, JAN Tooltip Japanese Accepted Name) in the case of the hydrochloride salt, is a sympathomimetic and bronchodilator medication which is marketed ...
An adrenergic agonist is a drug that stimulates a response from the adrenergic receptors.The five main categories of adrenergic receptors are: α 1, α 2, β 1, β 2, and β 3, although there are more subtypes, and agonists vary in specificity between these receptors, and may be classified respectively.
Vibegron is, in contrast to other OAB drugs, very selective and leads to a lesser degree of unwanted side effects. Vibegron is found to be a substrate for CYP3A4 in vivo, but does not actually induce or inhibit any of the cytochrome P450 enzymes and is thus less likely to take part in drug–drug interactions (DDI).
Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure. [3] This may be done if the blood pressure is very high and resulting in symptoms, in certain types of heart failure, and during surgery to decrease bleeding. [3]