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Orthostatic hypotension; Nasal congestion; Dizziness; Lack of energy; Headache; Drowsiness [2] [10] Tamsulosin: Flomax A blocker that has slight selectivity for α 1 receptors. [2] Relaxation of prostatic smooth muscle. [2] Benign prostatic hyperplasia [2] [11] Orthostatic hypotension [2] Yohimbine: Yocon
As discussed above, tamsulosin may have less risk for low blood pressure and orthostatic hypotension due to its selectivity for α 1a-adrenergic receptors. On the other hand, the drug (a) elevates risk for floppy iris syndrome, and (b) might show adverse drug reactions (ADRs) characteristic of the sulfa related drugs.
Orthostatic hypotension, also known as postural hypotension, [2] is a medical condition wherein a person's blood pressure drops when they are standing up (orthostasis) or sitting down. Primary orthostatic hypotension is also often referred to as neurogenic orthostatic hypotension. [ 3 ]
Demonstration of orthostatic hypotension. The alpha-1 blockers are associated with the first-dose effect, which refers to the tachycardia response and orthostatic hypotension that caused by the systemic vasodilation at the initial administration of alpha-1 blockers. [3]
This postural hypotension usually happens shortly after the first dose is absorbed into the blood and can result in syncope (fainting). Syncope occurs in approximately 1% of patients given an initial dose of 2 mg prazosin or greater. This adverse effect is self-limiting and in most cases does not recur after the initial period of therapy or ...
Tamsulosin (used in benign prostatic hyperplasia ... This action is generally undesirable in such agents and mediates side effects like orthostatic hypotension, ...
Many tricyclic antidepressants, tetracyclic antidepressants, antipsychotics, ergolines, and some piperazines like buspirone, trazodone, nefazodone, etoperidone, and mepiprazole antagonize α 1-adrenergic receptors as well, which contributes to their side effects such as orthostatic hypotension.
The first-dose reaction can also result in tachycardia and orthostatic hypotension, which is characterised by a feeling of extreme dizziness that gets worse with an upright posture. [1] Intravascular volume reduction, or concomitant use of other antihypertensive drugs can also lead to reflex tachycardia and orthostatic hypotension. [8]
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