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The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy : a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain . [ 1 ]
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
Incubate at 23 °C (73 °F) for 20 minutes; Centrifuge for 20 minutes at 16,000 G at 23 °C (73 °F) Invert filter and spin for 3 minutes at 2000 G; Bring the sample back to a neutral pH with 15-2uL 2.5M Tris pH9; Add ELISA buffer (1.5% BSA and 0.05% Tween 20 in phosphate buffered saline) Perform ELISA analysis.
The normal function of Aβ is not yet known. [9] Though some animal studies have shown that the absence of Aβ does not lead to any obvious loss of physiological function, [10] [11] several potential activities have been discovered for Aβ, including activation of kinase enzymes, [12] [13] protection against oxidative stress, [14] [15] regulation of cholesterol transport, [16] [17] functioning ...
4804 18053 Ensembl ENSG00000064300 ENSMUSG00000000120 UniProt P08138 Q9Z0W1 RefSeq (mRNA) NM_002507 NM_033217 RefSeq (protein) NP_002498 NP_150086 Location (UCSC) Chr 17: 49.5 – 49.52 Mb Chr 11: 95.46 – 95.48 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR ...
11640 Ensembl ENSG00000121057 ENSMUSG00000018428 UniProt Q92667 O08715 RefSeq (mRNA) NM_001242902 NM_001242903 NM_003488 NM_139275 NM_001370423 NM_001370424 NM_001370425 NM_001370426 NM_001370427 NM_001042541 NM_009648 RefSeq (protein) NP_001229831 NP_001229832 NP_003479 NP_001357352 NP_001357353 NP_001357354 NP_001357355 NP_001357356 NP_001036006 NP_033778 Location (UCSC) Chr 17: 57.09 – 57 ...
Phosphorylase kinase (PhK) is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen.PhK phosphorylates glycogen phosphorylase at two serine residues, triggering a conformational shift which favors the more active glycogen phosphorylase "a" form over the less active glycogen phosphorylase b.
It also acts on the brain's cholinergic system; [4] Amyloid β containing pyroglutamic acid is increased in Alzheimer's disease; this may be part of the disease process. [5] Increased levels of pyroglutamic acid in the blood, leading to excess in the urine ( 5-oxoprolinuria ), can occur following paracetamol overdose , as well as in certain ...
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