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These antibodies are transported from the plasma cells by the blood plasma and the lymphatic system to the site of the target antigen (foreign substance), where they initiate its neutralization or destruction. B cells differentiate into plasma cells that produce antibody molecules closely modeled after the receptors of the precursor B cell. [3]
Long-lived plasma cells (LLPCs) are a distinct subset of plasma cells that play a crucial role in maintaining humoral memory and long-term immunity. [1] They continuously produce and secrete high-affinity antibodies into the bloodstream, conversely to memory B cells , which are quiescent and respond quickly to antigens upon recall.
Differentiation of memory B cells into plasma cells is far faster than differentiation by naïve B cells, which allows memory B cells to produce a more efficient secondary immune response. [4] The efficiency and accumulation of the memory B cell response is the foundation for vaccines and booster shots.
B cell activation: from immature B cell to plasma cell or memory B cell Basic B cell function: bind to an antigen, receive help from a cognate helper T cell, and differentiate into a plasma cell that secretes large numbers of antibodies. B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. [1]
The GC B cells that differentiate into memory B cells are distinct from plasma cell precursors, as they show lower affinity for the antigen [3] [6] and do not need much help from T follicular helper cells. Because of this, many scientists believe that memory B cell precursors are B cells from the light zone that were "non-positively selected."
In the course of an immune response, B cells can progressively differentiate into antibody-secreting cells or into memory B cells. [6] Antibody-secreting cells comprise plasmablasts and plasma cells, which differ mainly in the degree to which they secrete antibody, their lifespan, metabolic adaptations, and surface markers. [7]
In immunology, a naive B cell is a B cell that has not been exposed to an antigen. These are located in the tonsils, spleen, and primary lymphoid follicles in lymph nodes. Once exposed to an antigen, the naive B cell either becomes a memory B cell or a plasma cell that secretes
TH17 cells do a variety of tasks including recruiting neutrophils, creating defensins, and mediating inflammation in the intestinal epithelium and skin. TH2 cells produce cytokines that will trigger certain B cells. B cells can differentiate into memory cells or plasma cells. The B plasma cells produce the antibodies that are used to tag