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[6] Drugs in the oxime class (e.g., Pralidoxime) reactivate AChE by removing the OP. Oximes have a higher affinity for phosphorylation than the serine residue in the AChE active site, causing the OP to detach from the AChE enzyme, freeing its active site and restoring function.
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
The property of the GAL1-GAL10 to bind the GAL4 protein is utilised in the GAL4/UAS technique for controlled gene mis-expression in Drosophila. This is the most popular form of binary expression in Drosophila melanogaster, a system which has been adapted for many uses to make Drosophila melanogaster one of the most genetically tractable multicellular organisms. [5]
The WD repeats in cdh1 are suspected to be the binding sites for the APC/c substrates. Thus cdh1 seems to be a sort of linker between the APC/c complex and the substrates. The APC/c substrates contain a D-Box and/or a KEN-Box, which are important for the interaction with cdh1. [9] [13] [14] [15]
Activator may refer to: Activator (genetics) , a DNA-binding protein that regulates one or more genes by increasing the rate of transcription Activator (phosphor) , a type of dopant used in phosphors and scintillators
The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators): . p300 (also called EP300 or E1A binding protein p300)
Aspartate carbamoyltransferase (also known as aspartate transcarbamoylase or ATCase) catalyzes the first step in the pyrimidine biosynthetic pathway (EC 2.1.3.2). [1]In E. coli, the enzyme is a multi-subunit protein complex composed of 12 subunits (300 kDa in total). [2]
The tool's design is based on a dental impactor, [6] a device that taps dental amalgam into cavities in teeth. [4] Activator I was patented by Activator Methods International on September 26, 1978. [4] [7] [8] Activator II was released, with an added "impedance head", in 1994. [4]